Van de Weyer served as Belgium’s Prime minister from July 1845 to March 1846. However, he lived for the majority of his life in London (17 Fitzroy Square, 50 Portland Place) and Windsor (New Lodge), and held the office of Belgian Minister at the Court of St. James’s under Queen Victoria, an ambassadorial role. Van de Weyer was close friends with Lord Palmerston. In addition to being a member of the Roxburghe Club, Van de Weyer was a founder member of the Philobiblon Society, the Vice President of the London Library, a Member of the Société des Bibliophiles de Belgique and the Head of the Royal Library of Brussels.Pierre Henri Laurent said of Van de Weyer: 'His manners, taste, and savoir-faire brought him into the vital center of the intellectual, diplomatic, and financial communities. His home became the meeting place of writers, artists, and scientists’.